Welcome to the Chen Lab
Our laboratory is interested in the structure and function of molecular complexes that control cell signaling and gene expression. We use a multi-disciplinary approach that combines structural biology, chemical biology, biochemistry/cell biology, and computational biology/bioinformatics to study the molecular basis of signal transduction and transcription regulation.
Congratulations to Dr. Aidong Han, a major study from his independent lab: "Mechanistic Insights Revealed by the Crystal Structure of a Histidine Kinase with Signal Transducer and Sensor Domains", has just been accepted for publication by PLOS Biology.
Congratulations to Yongheng, Darren, their studies of DNA bridging by GATA3 have been accepted for publications by Cell Reports. Congratulations also to Raja Dey and our collaborators Po-Han chen, Ite Laird, Carolina Machado, Remo Rohs, who also contributed to this work.
Congratulations to Reza for winning the Harrison M. Kurtz Award as the most outstanding Ph.D. student in the biological sciences.
Congratulations to Nimanthi, her studies on the inhibition of the MEF2:class IIa HDAC complex has just been accepted by Nucleic Acids Research. Congratulations also to our collaborator of the Petasis lab, Kevn Gaffney, Jamie Jarusiewicz. Aidong, Raja, Kaori, Michael, Xiao, Ju, Jun and Tao also contributed to this study.
Congratulations to Reza and also Nimanthi, our collaborators Frank Alber and Harianto Tjong, the TCC study of human genome structure has been accepted for publication by Nature Biotechnology.
Yongheng Chen, Darren Bates, Raja Dey, Po-Han Chen, Ana Carolina Dentas Machado, Ite A Laird-Offringa, Remo Rohs, Lin Chen " DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation", Cell Reports. Accepted, Sept. 5, 2012
Nimanthi Jayathilaka, Aidong Han, Kevin J Gaffney, Raja Dey, Jamie A Jarusiewicz, Kaori Noridomi, Michael A Philips, Xiao Lei, Ju He, Jun Ye, Tao Gao, Nicos A Petasis, Lin Chen "Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2" Nucleic Acid Research, Mar. 6, 2012
Reza Kalhor, Harianto Tjong, Nimanthi Jayathilaka, Frank Alber1, and Lin Chen "Genome architectures revealed by tethered chromosome conformation capture and population-based modeling" Nature Biotechnology, 30, 90-98, 2012
Shu-Xing Li, Sun Huang, Nina Bren, Kaori Noridomi1, Cosma D. Dellisanti, Steven M. Sine and Lin Chen "Crystal Structures of the Ligand Binding Domain of a Pentameric alpaha 7 Nicotinic Receptor Chimera and its Complex with Agonist" Nature Neuroscience, 14, 1253, 2011
Hozefa Bandukwala, Yongqing Wu, Markus Feurer, Yongheng Chen, Bianca Barbosa, Kian P. Koh, Srimoyee Ghosh, Mark S. Sundrud, James C. Stroud, Christophe Benoist, Diane Mathis, Anjana Rao, & Lin Chen "Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells" Immunity, 34, 479, 2011.