04/2012

Congratulations to Reza for winning the Harrison M. Kurtz Award as the most outstanding Ph.D. student in the biological sciences.

02/2012

Congratulations to Nimanthi, her studies on the inhibition of the MEF2:class IIa HDAC complex has just been accepted by Nucleic Acids Research. Congratulations also to our collaborator of the Petasis lab, Kevn Gaffney, Jamie Jarusiewicz. Aidong, Raja, Kaori, Michael, Xiao, Ju, Jun and Tao also contributed to this study.

10/2011

Congratulations to Reza and also Nimanthi, our collaborators Frank Alber and Harianto Tjong, the TCC study of human genome structure has been accepted for publication by Nature Biotechnology.

Recent publications:

Nimanthi Jayathilaka, Aidong Han, Kevin J Gaffney, Raja Dey, Jamie A Jarusiewicz, Kaori Noridomi, Michael A Philips, Xiao Lei, Ju He, Jun Ye, Tao Gao, Nicos A Petasis, Lin Chen "Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2" Nucleic Acid Research, Mar. 6, 2012

Reza Kalhor, Harianto Tjong, Nimanthi Jayathilaka, Frank Alber1, and Lin Chen "Genome architectures revealed by tethered chromosome conformation capture and population-based modeling" Nature Biotechnology, 30, 90-98, 2012

Shu-Xing Li, Sun Huang, Nina Bren, Kaori Noridomi1, Cosma D. Dellisanti, Steven M. Sine and Lin Chen "Crystal Structures of the Ligand Binding Domain of a Pentameric alpaha 7 Nicotinic Receptor Chimera and its Complex with Agonist" Nature Neuroscience, 14, 1253, 2011

Hozefa Bandukwala, Yongqing Wu, Markus Feurer, Yongheng Chen, Bianca Barbosa, Kian P. Koh, Srimoyee Ghosh, Mark S. Sundrud, James C. Stroud, Christophe Benoist, Diane Mathis, Anjana Rao, & Lin Chen "Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells" Immunity, 34, 479, 2011.

Ju He, Jun Ye, Yongfei Cai, Cecilia Riquelme, Jun O. Liu, Xuedong Liu, Aidong Han, and Lin Chen "Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly" Nucleic Acid Research, 39, 4464, 2011