Welcome to the Chen Lab

Our laboratory is interested in the structure and function of molecular complexes that control cell signaling and gene expression. We use a multi-disciplinary approach that combines structural biology, chemical biology, biochemistry/cell biology, and computational biology/bioinformatics to study the molecular basis of signal transduction and transcription regulation.

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Research Highlight
Our research has been supported in part by NIH (NIGMS, NIAID, NHLB), the Damon Runyon-Walter Winchell Foundation, and the W.M. Keck foundation. Grants (NFAT, MEF2 , HDACi and FOXP)

  News

10/2009

We have won a challenge grant (1RC1DA028790) for developing mechanism -based small molecule epigenetic modulators

08/2009

Congratulations to Dr.Yongheng Chen for getting an NIH postdoctoral fellowship!

01/2010

Happy New Year.

Recent publications:

Yongqing Wu, Raja Dey, Aidong Han, Nimanthi Jayathilaka, Michael Philips, Jun Ye, & Lin Chen "Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for the myocardin recruitment." J. Mol. Biol.,, accepted, 2010

Lin Chen “In pursuit of high-resolution structure of nicotinic acetylcholine receptors.” J. Physiology, Dec. 7. 2009,

Yongheng Chen, Raja Dey & Lin Chen “Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer”. Structure, 18, 1-11, 2010

J.C. Stroud, A. Oltman, A. Han, D. L. Bates, and L. Chen “Structural basis of HIV-1 activation by NF-kappaB-a higher-order complex of p50:RelA bound to the HIV-1 LTR”. J. Mol. Biol., 393, 98-112, 2009

S.H. Meijsing, M. Pufall, A So., D.L. Bates, L. Chen, and K.R. Yamamoto “DNA binding site sequence directs Glucocorticoid receptor structure and function”, Science, 324, 407-410, 2009