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Welcome to the Chen Lab Our laboratory is interested in the structure and function of molecular complexes that control cell signaling and gene expression. We use a multi-disciplinary approach that combines structural biology, chemical biology, biochemistry/cell biology, and computational biology/bioinformatics to study the molecular basis of signal transduction and transcription regulation. |
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10/2009 We have won a challenge grant (1RC1DA028790) for developing mechanism -based small molecule epigenetic modulators 08/2009 Congratulations to Dr.Yongheng Chen for getting an NIH postdoctoral fellowship! 01/2010 Happy New Year. Recent publications: Yongqing Wu, Raja Dey, Aidong Han, Nimanthi Jayathilaka, Michael Philips, Jun Ye, & Lin Chen "Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for the myocardin recruitment." J. Mol. Biol.,, accepted, 2010 Lin Chen In pursuit of high-resolution structure of nicotinic acetylcholine receptors. J. Physiology, Dec. 7. 2009, Yongheng Chen, Raja Dey & Lin Chen Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. Structure, 18, 1-11, 2010 J.C. Stroud, A. Oltman, A. Han, D. L. Bates, and L. Chen Structural basis of HIV-1 activation by NF-kappaB-a higher-order complex of p50:RelA bound to the HIV-1 LTR. J. Mol. Biol., 393, 98-112, 2009 S.H. Meijsing, M. Pufall, A So., D.L. Bates, L. Chen, and K.R. Yamamoto DNA binding site sequence directs Glucocorticoid receptor structure and function, Science, 324, 407-410, 2009 |