Welcome to the Chen Lab

Our laboratory is interested in the structure and function of molecular complexes that control cell signaling and gene expression. We use a multi-disciplinary approach that combines structural biology, chemical biology, biochemistry/cell biology, and computational biology/bioinformatics to study the molecular basis of signal transduction and transcription regulation.

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Research Highlight
Our research has been supported in part by NIH (NIGMS, NIAID, NHLB), the Damon Runyon-Walter Winchell Foundation, and the W.M. Keck foundation. Grants (NFAT, MEF2 and FOXP)

  News

08/2009

Kaori Noridomi has been awarded a Department of Chemsitry Predoctoral Scholarship, congratulations!

06/2009

Congratulations to Dr.Yongheng Chen for getting an NIH postdoctoral fellowship!

04/2009

Congratulations to Shiyu (Shery) Bai for winning the WiSE summer research fellowship!

Recent publications:

J.C. Stroud, A. Oltman, A. Han, D. L. Bates, and L. Chen “Structural basis of HIV-1 activation by NF-kappaB-a higher-order complex of p50:RelA bound to the HIV-1 LTR”. J. Mol. Biol., Accepted, 2009

S.H. Meijsing, M. Pufall, A So., D.L. Bates, L. Chen, and K.R. Yamamoto “DNA binding site sequence directs Glucocorticoid receptor structure and function”, Science, 324, 407-410, 2009

R. Dey, K. Ji, Z. Liu, L. Chen, “A cytokine-cytokine interaction in the assembly of higher-order structure and activation of the interleukine-3:receptor complex”, PLoS ONE, 4, 4, p1-12, 2009

D.L. Bates, Y. Chen, G. Kim, L. Guo, L. Chen, “Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA” J. Mol. Biol., , 381,1292, 2008

D.L. Bates, K.K. Barthel, Y. Wu, R. Kalhor, J.C. Stroud, M.J. Giffin, L. Chen, “Crystal Structure of NFAT Bound to the HIV-1 LTR Tandem kappaB Enhancer Element” Structure, 16, p684-94, 2008